Sodium Carbonate → HCID 178485839, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.200 g 1-(6-amino-4-cyano-pyridin-2-yl)-3-methyl-urea (example 23a) in 3.2 ml ethanol and 1.6 ml water was added 0.145 g hydroxylamine hydrochloride and 0.333 g sodium carbonate and the mixture was stirred at 85° C. for 2 h. The reaction mixture was purified by solid phase extraction with ethyl acetate to yield 0.154 g of the title compound as light yellow solid. MS (ISP) M+H+=225.1

Provenance & Evidence