Acetic Anhydride → HCID 67273765, compound

Participants

Reaction Steps

A solution of 0.134 g 2,6-diamino-N-hydroxy-isonicotinamidine (Example 108a) in 2.00 ml acetic acid anhydride was heated to reflux for 4 h. The reaction mixture was partitioned between water and ethyl acetate. The phases were separated and the organic phase was dried over magnesium sulfate dihydrate and evaporated. The residue was taken up in 2 ml 2N hydrochloric acid and heated to reflux for 1.5 h. The mixture neutralized by addition of 3 ml 1N sodium hydroxide and partitioned between water and ethyl acetate. The phases were separated and the organic phase was washed with brine and evaporated to yield 0.071 g of the title compound as brown solid.

Provenance & Evidence