Sodium Carbonate → HCID 178503297, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.179 g 6-amino-4-methylsulfanyl-pyridine-2-carbonitrile in 2.7 ml ethanol and 1.3 ml water was added 0.151 g hydroxylamine hydrochloride and 0.344 g sodium carbonate and the mixture was stirred at 85° C. for 1 h. The mixture was charged onto a 10 g kartusche (Varian Chem Elut 12198007) and the product was eluted with ethyl acetate and purified by chromatography on silica gel with dichloromethane:methanol:ammonia=8:2:0.2 to yield 0.120 g of the title compound as white solid. MS (ISP) M+H+=199.0

Provenance & Evidence