Methanol → HCID 66859659, compound

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A mixture of (4-{4-[4-(bis-{2-[3-(benzylmethanesulfonylamino)-4-benzyloxyphenyl]-2-(R)-hydroxyethyl}amino)butyl]phenyl}butyl)carbamic acid benzyl ester (38) (0.45 g, 0.383 mmol), palladium dihydroxide (0.12 g, 10% Pd(OH)2 on carbon, 50% wet), ten drops of acetic acid, methanol (12 mL), and dichloromethane (6 mL) was stirred at rt for 18 h under atmospheric hydrogen pressure. The catalyst was removed by vacuum filtration through a Celite pad and the filtrate was concentrated by rotary evaporation and further dried under high vacuum to give the desired amine diacetic acid salt 41 as a white solid (0.30 g, 98%): m/z (ESI) 679 [C32H42N4O6+H]+.

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