HCID 58100080, compound → HCID 58100137, compound

Participants

Reaction Steps

A suspension containing 65 (250 mg, 0.28 mmol) and palladium catalyst (10% Pd on carbon, 50% wet, 100 mg, 0.94 mmol) in ethanol (10 mL) was bubbled with nitrogen for 20 min. The reaction mixture was vacuumed, then charged with H2 gas (1 atm), and allowed to stir at room temperature for 24 h. The suspension was filtered and the filtrate was concentrated in vacuo. The resulting residue was purified by column chromatography eluting with a mixture of 0-20% (10% concentrated ammonium hydroxide in methanol and dichloromethane to afford the desired product 66 (45 mg, 28%) as an off white solid: m/z (ESI) 553 [C32H44N2O6+H]+.

Provenance & Evidence