Hydrazine → HCID 178432945, compound

HRID 1696865Notes

Reaction equation

HRID 1696865 reaction equation
[CH3:1][C:2]1[N:6]=[C:5]([CH3:7])[N:4]([CH:8]([C:19](=O)[CH3:20])[C:9]([O:11]CC2C=CC=CC=2)=O)[N:3]=1.[NH2:22][NH2:23]>CCO>[CH3:1][C:2]1[N:6]=[C:5]([CH3:7])[N:4]([C:8]2[C:19]([CH3:20])=[N:23][NH:22][C:9]=2[OH:11])[N:3]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 67274297benzyl 2-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-oxobutanoate

Product 1

HCID 178432945HCID 178432945, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture comprising benzyl 2-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-oxobutanoate (step 2) (7.1 g, 24.71 mmol) and hydrazine (2.327 ml, 74.1 mmol) in EtOH (124 ml) were stirred at 50° C. for 3 hours. The reaction was allowed to cool to RT overnight. The resultant solid was then collected by filtration and washed with a small amount of cold EtOH to afford the title compound as a pale yellow solid; LC-MS Rt 0.61 mins; MS m/z 193.9 [M+H]+; Method=Method LowpH_v001.

Workup

  1. filtrationThe resultant solid was then collected by filtration
  2. washwashed with a small amount of cold EtOH

Sources & evidence

ORD record
ord-076c11d6c2fb4c55acac65e13352e64b
Source dataset
uspto-grants-2012_04
Patent number
US08163785B2

Reaction notes

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