反应详情

Starting with (5-amino-5,6,7,8-tetrahydro-naphthalen-1-yloxy)-acetic acid tert-butyl ester (example 1-1, method A, 3rd step) (0.500 g, 1.8 mmol), diisopropylamine (0.553 g, 2.1 mmol) and 4-bromobenzenesulfonyl chloride (0.465 g, 1.8 mmol), using the method analogous to the one described for example 1-1, method A, 4th step, [5-(4-bromo-benzenesulfonylamino)-5,6,7,8-tetrahydro-naphthalen-1-yloxy]-acetic acid tert-butyl ester (0.53 g, 61%) was obtained. MS cald. for C22H26BrNO5S 495, obsd. 496 [(M+H)+].