Lithium Hydroxide → HCID 44816532, compound

Participants

Reaction Steps

(R)-[5-(2′-Chloro-biphenyl-4-sulfonylamino)-5,6,7,8-tetrahydro-naphthalen-1-yloxy]-acetic acid tert-butyl ester was treated with aqueous lithium hydroxide (0.2 M, 1 mL) in tetrahydrofuran (1 mL) overnight, at room temperature. The reaction mixture was concentrated in vacuo. Reverse phase HPLC (Pursuit C-18, 20×150 mm, water/acetonitrile/0.05% trifluoroacetic acid) gave (R)-[5-(2′-chloro-biphenyl-4-sulfonylamino)-5,6,7,8-tetrahydro-naphthalen-1-yloxy]-acetic acid (8.5 mg, 43% over two steps). MS cald. for C24H22ClNO5S 471, obsd. 472 [(M+H)+].

Provenance & Evidence