(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine → HCID 67274857, compound

HRID 1696893Notes

Reaction equation

HRID 1696893 reaction equation
Cl[C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:28])[C:7]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:8][N:9]2[CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:14]=2[O:21][CH3:22])=[C:4]([CH3:29])[C:3]=1[F:30].[C:31]([O:35][C:36]([NH:38][CH:39]1[CH2:43][CH2:42][NH:41][CH2:40]1)=[O:37])([CH3:34])([CH3:33])[CH3:32].[C:44](OC(N[C@@H]1CCNC1)=O)(C)(C)C>>[C:31]([O:35][C:36]([NH:38][CH:39]1[CH2:43][CH2:42][N:41]([C:2]2[N:11]=[C:10]3[C:5]([C:6](=[O:28])[C:7]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:8][N:9]3[CH2:12][C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:14]=3[O:21][CH3:22])=[C:4]([CH2:29][CH3:44])[C:3]=2[F:30])[CH2:40]1)=[O:37])([CH3:34])([CH3:32])[CH3:33]

Participants

4

Reactant 3

HCID 1514397(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidineHCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamateHCID 86590508HCID 86590508, compound

Product 1

HCID 67274857HCID 67274857, compound

Procedure

This example was prepared by substituting ethyl 7-chloro-1-(2,4-dimethoxybenzyl)-6-fluoro-5-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate for ethyl 7-chloro-1-(2,4-dimethoxybenzyl)-6-fluoro-5-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate and 3-(tert-butoxycarbonylamino)pyrrolidine for (3R)-3-(tert-butoxycarbonylamino)pyrrolidine in EXAMPLE 1E.

Sources & evidence

ORD record
ord-a372f886e7be46efa5162207ea8f0aeb
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

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