Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | HCID 67274864 | HCID 67274864 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 67275192 | HCID 67275192 | — |
Reaction Steps
A suspension of EXAMPLE 15B (260 mg) in ethanol (60 mL) was treated with HCl gas to saturation, heated at 120° C. for 18 hours then cooled, treated with diethyl ether and filtered to provide the desired product. NMR (300 MHz, DMSO-d6) δ 13.32 (d, 1H), 8.42 (d, 1H), 8.36 (br s, 3H), 8.02 (d, 1H), 4.05-3.83 (m, 5H), 2.44-2.25 (m, 1H), 2.20-2.12 (m, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08163769B2 |
|---|
| Source dataset | uspto-grants-2012_04 |
|---|
| ORD ID | ord-6d0652c368544615add775f5907877e6 |
|---|
| Source note | uspto-grants-2012_04 |
|---|
