HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Tributylstannyl)furan → Ethyl 1-(2,4-dimethoxybenzyl)-6-fluoro-7-(2-furyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Tributylstannyl)furan | HCID 4393688 | — |
| Reactant | Ethyl 7-chloro-1-(2,4-dimethoxybenzyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate | HCID 13937202 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl 1-(2,4-dimethoxybenzyl)-6-fluoro-7-(2-furyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate | HCID 67275183 | — |
Reaction Steps
A solution of Example 7F (210 mg), 2-(tributylstannyl)furan (220 μL) and dichlorobis(triphenyl-phosphine)palladium (II) (10.5 mg) in toluene (8 mL) was heated at 80° C. for 3 hours then cooled and filtered through diatomaceous earth (Celite®) with ethyl acetate. The filtrate was dried (Na2SO4), filtered, and concentrated; and the concentrate was flash chromatographed on silica gel with heptane then dichloromethane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163769B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-a8643dcb8e1e443d8d92ab4ca2d3cd1a |
| Source note | uspto-grants-2012_04 |