Lithium hydroxide, monohydrate → HCID 10082940, compound

Participants

Reaction Conditions

Reaction Steps

A solution of Example 65D (0.200 g) in 1.4-dioxane (5 mL) was treated with lithium hydroxide monohydrate (0.100 g), stirred for 16 hours, and concentrated. The concentrate was dissolved in trifluoroacetic acid (8 mL), heated at 60° C. for 12 hours, and concentrated; and this concentrate was purified by reverse phase HPLC to afford the desired product. NMR (300 MHz, DMSO-d6) δ 14.95 (s, 1H), 13.79 (s, 1H), 8.72 (s, 1H), 7.57 (s, 1H), 2.89 (s, 3H).

Provenance & Evidence