4-(N-Boc-amino)piperidine → HCID 67275302, compound

HRID 1696920Notes

Reaction equation

HRID 1696920 reaction equation
Cl[C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:21])[C:7]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:8][N:9]2[CH2:12][CH2:13][C:14]#[N:15])=[CH:4][C:3]=1[F:22].[NH:23]1[CH2:28][CH2:27][CH:26]([NH:29][C:30](=[O:36])[O:31][C:32]([CH3:35])([CH3:34])[CH3:33])[CH2:25][CH2:24]1>ClCCl>[C:32]([O:31][C:30]([NH:29][CH:26]1[CH2:25][CH2:24][N:23]([C:2]2[N:11]=[C:10]3[C:5]([C:6](=[O:21])[C:7]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:8][N:9]3[CH2:12][CH2:13][C:14]#[N:15])=[CH:4][C:3]=2[F:22])[CH2:28][CH2:27]1)=[O:36])([CH3:35])([CH3:33])[CH3:34]

Participants

4

Reactant 2

HCID 7238334-(N-Boc-amino)piperidineHCID 87333591HCID 87333591, compound

Product 1

HCID 67275302HCID 67275302, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of EXAMPLE 7C (0.5 g) and 1,1-dimethylethyl piperidin-4-ylcarbamate in dichloromethane (100 mL) was stirred for 2 hours, diluted with dichloromethane (100 mL), washed with water, 10% citric acid, and brine, and dried (MgSO4), filtered, and concentrated.

Workup

  1. washwashed with water, 10% citric acid, and brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-3f6dd00fab0a4de7b5b8065bcd4eaf48
Source dataset
uspto-grants-2012_04
Patent number
US08163769B2

Reaction notes

Loading…