1,4-Dioxane hydrochloride → HCID 10357072, compound

Participants

Reaction Steps

A solution of EXAMPLE 80A (160 mg) in 1:1 9M HCl/1,4-dioxane (15 mL) was heated in a sealed tube at 115° C. for 15 minutes and at 95° C. for 24 hours then cooled, diluted with water (20 mL), and filtered. NMR (300 MHz, DMSO-d6) δ 15.25 (s, 1H), 13.11 (br s, 1H), 8.47 (s, 1H), 8.18 (s, 1H), 3.84-3.80 (m, 4H), 1.96-1.91 (m, 4H).

Provenance & Evidence