HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Ethyl (2Z)-2-((2,6-dichloropyridin-3-yl)carbonyl)-3-(dimethylamino)prop-2-enoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,6-Dichlorpyridine-3-carbonyl chloride | HCID 12263984 | — |
| Reactant | Ethyl 3,3-dimethylaminoacrylate | HCID 85819813 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl (2Z)-2-((2,6-dichloropyridin-3-yl)carbonyl)-3-(dimethylamino)prop-2-enoate | HCID 15675736 | — |
Reaction Steps
A solution of 2,6-dichloronicotinoyl chloride (62.5 g), ethyl 3,3-dimethylaminoacrylate (58.8 g) and triethylamine (69 g) in toluene (600 mL) was stirred at 90° C. for 1 hour then cooled and concentrated. The concentrate was dissolved in dichloromethane (60 mL), diluted with diethyl ether, and filtered. The filtrate was concentrated, and the concentrate was crystallized from dichloromethane/diethyl ether/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163769B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-59468fef94ac434f8f11f2f60a94b9e2 |
| Source note | uspto-grants-2012_04 |