HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dibromo-5,5-dimethylhydantoin → Ethyl 7-azetidin-1-yl-6-bromo-1-(2-cyanoethyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dibromo-5,5-dimethylhydantoin | HCID 6479 | — |
| Reactant | Ethyl 7-azetidin-1-yl-1-(2-cyanoethyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate | HCID 67275510 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | Ethyl 7-azetidin-1-yl-6-bromo-1-(2-cyanoethyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate | HCID 67275613 | — |
Reaction Steps
A solution of EXAMPLE 81C (0.50 g) and 1,3-dibromo-5,5-dimethylhydantoin (0.26 g) in chloroform (100 mL) was refluxed for 10 minutes then cooled, diluted with chloroform, washed with 10% sodium bisulfate and brine, dried (MgSO4), filtered, and concentrated; and the concentrate was crystallized from dichloromethane/ethyl acetate/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163769B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-2c53c91670054f589f5accb41e7e45ba |
| Source note | uspto-grants-2012_04 |