HRID1696944

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID25517

未命名化合物

结构：CCOC(=O)c1cn(Cc2ccc(OC)cc2OC)c2nc(N3C[C@@H]4C[C@H]3CN4C(=O)OC(C)(C)C)c(F)cc2c1=O

HCID67274956

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(Cn2cc(C(=O)O)c(=O)c3cc(F)c(N4C[C@@H]5C[C@H]4CN5C(=O)OC(C)(C)C)nc32)c(OC)c1

HCID67275078

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A solution of EXAMPLE 84A in 1:1 ethanol/1M NaOH (20 mL) was heated at 80° C. for 18 hours then cooled, poured into saturated ammonium chloride (100 mL), and filtered.

WORKUP

后处理

temperaturethen cooled
filtrationfiltered

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1334da4b5c034c5cade0b1a24e5fb153
来源数据集: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08163769B2
来源说明: uspto-grants-2012_04

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][C@@H:12]2[CH2:14][C@H:9]1[CH2:10][N:11]2[C:15]1[N:24]=[C:23]2[C:18]([C:19](=[O:41])[C:20]([C:36]([O:38]CC)=[O:37])=[CH:21][N:22]2[CH2:25][C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:27]=2[O:34][CH3:35])=[CH:17][C:16]=1[F:42])=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl-].[NH4+]>C(O)C>[C:1]([O:5][C:6]([N:8]1[CH2:13][C@@H:12]2[CH2:14][C@H:9]1[CH2:10][N:11]2[C:15]1[N:24]=[C:23]2[C:18]([C:19](=[O:41])[C:20]([C:36]([OH:38])=[O:37])=[CH:21][N:22]2[CH2:25][C:26]2[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:27]=2[O:34][CH3:35])=[CH:17][C:16]=1[F:42])=[O:7])([CH3:4])([CH3:2])[CH3:3]