Hydrochloric Acid → HCID 67275454, compound

Participants

Reaction Steps

A solution of EXAMPLE 244B (0.027 g) in trifluoroacetic acid (2 mL) was heated at 75° C. for 18 hours, and concentrated with a toluene azeotrope; and the residue was purified on a reverse phase HPLC on a C8 column with 10-95% acetonitrile in water containing 0.1% trifluoroacetic acid to provide an oily compound. A solution of the oily compound in 1:1 of methanol/dichloromethane was treated with 2N HCl in diethyl ether (0.5 mL), and concentrated. NMR (DMSO-d6) δ ppm 13.34 (m, 1H), 9.72 (bs, 2H), 8.51 (d, 1H), 8.05 (d, 1H), 7.63 (m, 2H), 7.44 (m, 3H), 4.74 (bs, 1H), 4.40-4.00 (m, 5H), 3.70 (m, 2H).

Provenance & Evidence