HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Carbonyldiimidazole → N-[1-(2-pyridinyl)-4-piperidinyl]-1H-imidazole-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 1-(Pyridin-2-yl)piperidin-4-amine | HCID 10197934 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[1-(2-pyridinyl)-4-piperidinyl]-1H-imidazole-1-carboxamide | HCID 21978278 | — |
Reaction Steps
A stirred solution of CDI (1.1 g, 6.77 mmol) in DCM (100 ml) is treated with 3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-ylamine (WO 99/65895, EP 21973) (1 g, 5.64 mmol in 50 ml of DCM) added dropwise over 30 minutes. The reaction mixture is stirred at room temperature for 15 minutes to yield the titled compound as a 10 mg/ml solution in DCM.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163754B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-84339bc7990c41f68f39e596aa349314 |
| Source note | uspto-grants-2012_04 |