2-Chloropyridine → HCID 66736008, compound

HRID 1696972Notes

Reaction equation

HRID 1696972 reaction equation
C(O[C:6](=[O:13])[NH:7][C@@H:8]1[CH2:12][CH2:11][NH:10][CH2:9]1)(C)(C)C.Cl[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1>>[NH2:7][CH2:8][CH2:9][NH:10][C:6]([NH:7][C@@H:8]1[CH2:12][CH2:11][N:10]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH2:9]1)=[O:13]

Participants

3

Reactant 2

HCID 79772-ChloropyridineHCID 1514397(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine

Product 1

HCID 66736008HCID 66736008, compound

Procedure

The titled compound is prepared analogously to Intermediate D by replacing (S)-pyrrolidin-3-yl-carbamic acid tert-butyl ester with (R)-pyrrolidin-3-yl-carbamic acid tert-butyl ester and replacing 2-bromopyridine with 2-chloropyridine.

Sources & evidence

ORD record
ord-ca215177308f47b9a66b6cec76017f3f
Source dataset
uspto-grants-2012_04
Patent number
US08163754B2

Reaction notes

Loading…