N-(2-Aminoethyl)piperidine → N-{(1S,2R,3S,4R)-4-[6-(1-Ethyl-propylamino)-2-(2-piperidin-1-yl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide

Participants

Role	Name	HCID	Charge
Reactant	N-(2-Aminoethyl)piperidine	HCID 33944	—
Reactant	N-{(1S,2R,3S,4R)-4-[2-Chloro-6-(1-ethyl-propylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide	HCID 11647233	—
Reactant	[(1S,4R)-4-(2,6-Dichloro-purin-9-yl)-cyclopent-2-enyl]-propionyl-carbamic acid tert-butyl ester	HCID 86622633	—
Product	N-{(1S,2R,3S,4R)-4-[6-(1-Ethyl-propylamino)-2-(2-piperidin-1-yl-ethylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide	HCID 11547872	—

Reaction Steps

N-{(1S,2R,3S,4R)-4-[2-Chloro-6-(1-ethyl-propylamino)-purin-9-yl]-2,3-dihydroxy-cyclopentyl}-propionamide (the compound of Example 14) is reacted with 1-(2-aminoethyl)-piperidine to give the title compound using a procedure analogous to that of Example 9. MS (ES+) m/e 503 (MH+).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08163754B2
Source dataset	uspto-grants-2012_04
ORD ID	ord-0936acb91db34b16b34da34afa69ea96
Source note	uspto-grants-2012_04