HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-ethylhistamine → N-((1S,2R,3S,4R)-4-{6-Amino-2-[2-(1-ethyl-1H-imidazol-4-yl)-ethylamino]-purin-9-yl}-2,3-dihydroxy-cyclopentyl)-isobutyramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-ethylhistamine | HCID 44292270 | — |
| Reactant | N-[(1S,2R,3S,4R)-4-(6-Amino-2-chloro-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-isobutyramide | HCID 86622636 | — |
| Product | N-((1S,2R,3S,4R)-4-{6-Amino-2-[2-(1-ethyl-1H-imidazol-4-yl)-ethylamino]-purin-9-yl}-2,3-dihydroxy-cyclopentyl)-isobutyramide | HCID 11539817 | — |
Reaction Steps
N-[(1S,2R,3S,4R)-4-(6-Amino-2-chloro-purin-9-yl)-2,3-dihydroxy-cyclopentyl]-isobutyramide is reacted with and 2-(1-ethyl-1H-imidazol-4-yl)-ethylamine to give the title compound Lasing a procedure analogous to that of Example 9. MS (ES+) m/e 458 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163754B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-3fcb5432f081440dbcf58157ad89c089 |
| Source note | uspto-grants-2012_04 |