(9H-Fluoren-9-yl)methanamine → N-((1S,2R,3S,4R)-4-[2-Chloro-6-[(9H-fluoren-9-ylmethyl)-amino]-purin-9-yl]-2,3-dihydroxy-cyclopentyl)-propionamide

Participants

Role	Name	HCID	Charge
Reactant	(9H-Fluoren-9-yl)methanamine	HCID 14555239	—
Reactant	N-((1S,2R,3S,4R)-4-{2-chloro-6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-2,3-dihydroxy-cyclopentyl)-propionamide trifluoroacetate	HCID 86622652	—
Product	N-((1S,2R,3S,4R)-4-[2-Chloro-6-[(9H-fluoren-9-ylmethyl)-amino]-purin-9-yl]-2,3-dihydroxy-cyclopentyl)-propionamide	HCID 24898398	—

Reaction Steps

This compound is prepared analogously to N-((4S,2R,3S,4R)-4-{2-chloro-6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-2,3-dihydroxy-cyclopentyl)-propionamide trifluoroacetate (Example 50) by replacing 1-napthalenemethylamine with C-(9H-fluoren-9-yl)-methylamine.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08163754B2
Source dataset	uspto-grants-2012_04
ORD ID	ord-207665f0c8d6496690c3e68706f7dc0f
Source note	uspto-grants-2012_04