N-(2-Aminoethyl)piperidine → N-((1S,2R,3S,4R)-4-{2-[((R)-1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-2,3-dihydroxy-cyclopentyl)-propionamide trifluoroacetate

Participants

Reaction Steps

These compounds namely, N-((1S,2R,3S,4R)-4-{2-(4-amino-cyclohexylamino)-6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-2,3-dihydroxy-cyclopentyl)-propionamide trifluoroacetate (Example 67), N-((1S,2R,3S,4R)-2,3-dihydroxy-4-{2-[2-(1H-imidazol-4-yl)-ethylamino]-6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-cyclo pentyl)-propionamide trifluoroacetate (Example 68) and N-((1S,2R,3S,4R)-4-{2-[((R)-1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-2,3-dihydroxy-cyclopentyl)-propionamide trifluoroacetate (Example 69) are prepared analogously to N-{(1S,2R,3S,4R)-2,3-dihydroxy-4-[6-[(naphthalen-1-ylmethyl)-amino]-2-(2-piperidin-1-yl-ethylamino)-purin-9-yl]-cyclopentyl}-propionamide trifluoroacetate (Example 66) by replacing 2-piperidin-1-yl-ethylamine with the appropriate amine.

Provenance & Evidence