2-Aminopyridine → HCID 67274676, compound

HRID 1697031Notes

Reaction equation

[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[OH:8][C@@H:9]1[C@H:13]([OH:14])[C@@H:12]([NH:15][C:16](=[O:19])[CH2:17][CH3:18])[CH2:11][C@H:10]1[N:20]1[CH:28]=[N:27][C:26]2[C:21]1=[N:22][C:23]([N:44]1[CH2:48][CH2:47][C@@H:46]([NH:49][C:50]([N:52]3CCN(C)CC3)=[O:51])[CH2:45]1)=[N:24][C:25]=2[NH:29][CH2:30][CH:31]([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.N[C:60]1[CH:65]=[CH:64][CH:63]=[CH:62][N:61]=1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[C:38]1([CH:31]([C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH2:30][NH:29][C:25]2[N:24]=[C:23]([N:44]3[CH2:48][CH2:47][C@@H:46]([NH:49][C:50]([NH:52][C:60]4[CH:65]=[CH:64][CH:63]=[CH:62][N:61]=4)=[O:51])[CH2:45]3)[N:22]=[C:21]3[C:26]=2[N:27]=[CH:28][N:20]3[C@@H:10]2[CH2:11][C@H:12]([NH:15][C:16](=[O:19])[CH2:17][CH3:18])[C@@H:13]([OH:14])[C@H:9]2[OH:8])[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1

Participants

Reactant 2

HCID 104392-Aminopyridine

HCID 86622657HCID 86622657, compound

Product 1

HCID 67274676HCID 67274676, compound

Procedure

This compound is prepared analogously to 4-methyl-piperazine-1-carboxylic acid {(R)-1-[9-((1R,2S,3R,4S)-2,3-dihydroxy-4-propionylamino-cyclopentyl)-6-(2,2-diphenyl-ethylamino)-9H-purin-2-yl]-pyrrolidin-3-yl}-amide trifluoro acetate (Example 77) by replacing 1-methyl piperazine with 2-amino pyridine.

Sources & evidence

ORD record: ord-2a8f8b22452341a0b62dfb1348bea7ac
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163754B2

Reaction notes

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