Hydrochloride methanol → HCID 67276221, compound

HRID 1697042Notes

Reaction equation

HRID 1697042 reaction equation
[C:1]1([S:7]([CH:10]2[CH2:16][CH:15]3[N:17](C(OC(C)(C)C)=O)[CH:12]([CH2:13][CH2:14]3)[CH2:11]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO.[ClH:27]>CO>[ClH:27].[C:1]1([S:7]([CH:10]2[CH2:11][CH:12]3[NH:17][CH:15]([CH2:14][CH2:13]3)[CH2:16]2)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 67276259HCID 67276259, compound

Product 1

HCID 67276221HCID 67276221, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

To a methanol (5 mL) solution of tert-butyl 3-phenylsulfonyl-8-azabicyclo[3.2.1]octane-8-carboxylate (174 mg) was added a 4N-hydrogen chloride methanol solution, and the mixture was stirred at 60° C. for 3 hours. The solvent was distilled off under reduced pressure, and the resulting solid was washed with diethyl ether to give a crude product of the title compound as a colorless solid (141 mg).

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. washthe resulting solid was washed with diethyl ether

Sources & evidence

ORD record
ord-1b75e8d56dd9449fb7ac5abb0baceb83
Source dataset
uspto-grants-2012_04
Patent number
US08163898B2

Reaction notes

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