Trifluoroacetic acid → HCID 25182112, compound

Participants

Reaction Steps

A mixture of TFA and DCM (1:4, 5 mL) was added to 3-[4-(4-t-butoxycarbonylpiperazine-1-sulfonyl)-benzyl]-7-chloro-4-oxo-1-phenyl-1,4-dihydroquinoline-2-carboxylic acid methyl ester (48 mg, 0.07 mmol) and the resulting mixture stirred at RT for 2 h. The reaction mixture was evaporated under reduced pressure, and the oily solid residue was purified by flash chromatography (DCM/MeOH, 100:0 to 90:10) to afford 7-chloro-4-oxo-1-phenyl-3-[4-(piperazine-1-sulfonyl)-benzyl]-1,4-dihydro-quinoline-2-carboxylic acid methyl ester trifluoroacetate as an off-white powder. MS=552 [M+H]+; MP=203.0-205.0° C.

Provenance & Evidence