Tetra-n-butylammonium tribromide → HCID 59846182, compound

Participants

Reaction Steps

Tetrabutylammonium tribromide (72 mg, 0.15 mmol) was added to a solution of 3-(4-acetylbenzyl)-7-methyl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester (53 mg, 0.12 mmol) in MeOH (8 mL), and the resulting mixture stirred at RT overnight. The reaction mixture was concentrated under reduced pressure, and the crude residue purified by preparative TLC (EtOAc/hexane, 10/90) to afford 23 of 3-[4-(2-bromoacetyl)-benzyl]-7-methyl-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester as an off-white powder. MS=507 [M+H]+; MP=189.0-191.1° C.

Provenance & Evidence