反应详情

To a mixture of 1-(4-chloro-2-phenylaminophenyl)ethanone (0.401 g) and 4-formyl-N-(2-hydroxy-2-methylpropyl)-benzene sulfonamide (0.420 g) in MeOH (10 mL) was added NaOH (1.35 mL, 2 N, aq), and the mixture stirred overnight at RT. The product was concentrated under reduced pressure, washed with EtOAc, H2O and brine, then dried over Na2SO4. The partially-purified product was chromatographed on anhydrous silica (DCM for 0-10 min, then MeOH/DCM for 11-30 min) to provide 4-[3-(4-chloro-2-phenylaminophenyl)-3-oxo-propenyl]-N-(2-hydroxy-2-methylpropyl)-benzene sulfonamide (0.540 g).

1. concentrationThe product was concentrated under reduced pressure
2. washwashed with EtOAc, H2O and brine
3. dry with materialdried over Na2SO4
4. customThe partially-purified product was chromatographed on anhydrous silica (DCM for 0-10 min