HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1697085Generated: November 1, 2026
2-Oxopropanoyl chloride → N-(5-chloro-2-{3-[4-(2-hydroxy-2-methylpropylsulfamoyl)-phenyl]-propionyl}-phenyl)-2-oxo-N-phenyl-propionamide
https://huagongshe.com/reaction/1697085
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Oxopropanoyl chloride | HCID 521791 | — |
| Reactant | 4-[3-(4-chloro-2-phenylaminophenyl)-3-oxo-propyl]-N-(2-hydroxy-2-methylpropyl)-benzenesulfonamide | HCID 59846174 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-(5-chloro-2-{3-[4-(2-hydroxy-2-methylpropylsulfamoyl)-phenyl]-propionyl}-phenyl)-2-oxo-N-phenyl-propionamide | HCID 59846199 | — |
Reaction Steps
To 4-[3-(4-chloro-2-phenylaminophenyl)-3-oxo-propyl]-N-(2-hydroxy-2-methylpropyl)-benzenesulfonamide (0.138 g) in toluene (10 mL) was added 2-oxopropionyl chloride (0.3 mL), and the mixture heated at 120° C. for 3 h to form N-(5-chloro-2-{3-[4-(2-hydroxy-2-methylpropylsulfamoyl)-phenyl]-propionyl}-phenyl)-2-oxo-N-phenyl-propionamide, which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08163906B2 |
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| Source dataset | uspto-grants-2012_04 |
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| ORD ID | ord-1d1589d85a1b4355b0ee3418bc1b8af7 |
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| Source note | uspto-grants-2012_04 |
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