Methyl iodide → HCID 66815815, compound

Participants

Reaction Steps

3-(6-Mercaptopyridin-3-yl)-1-(6-methyl-2-phenylaminopyridin-3-yl)-propan-1-one (0.4 g) was dissolved in DMF (5 mL), and methyl iodide (0.05 mL) added, followed by K2CO3 (0.138 g). The reaction mixture was allowed to stand at RT for 2.5 h, then worked up in EtOAc/H2O. The organic layer was washed with LiCl (2×, 0.3 wt % aq), dried over MgSO4, filtered, concentrated, and chromatographed over silica (12 g, 1:2 EtOAc/hexane) to provide 1-(6-methyl-2-phenylamino-pyridin-3-yl)-3-(6-methylsulfanyl-pyridin-3-yl)-propan-1-one (0.23 g). M+H=264.

Provenance & Evidence