Water → HCID 66816229, compound

Participants

Reaction Steps

To 3-(6-methoxycarbonyl-pyridin-3-ylmethyl)-7-methyl-4-oxo-1-phenyl-1,4-dihydro[1,8]naphthyridine-2-carboxylic acid methyl ester (compound 100) (0.2 g) in THF (10 mL) was added LiOH.H2O (0.06 g) and H2O (2 mL), and the mixture stirred at RT for 1 h. The product was taken up in EtOAc, washed with H2O and HCl (2M, 2 mL), filtered, and worked up with EtOAc and H2O. The organic layer was dried over MgSO4, and concentrated to a yellow oil. The oil was taken up in EtOAc, washed with H2O, dried over MgSO4, and concentrated to a yellow solid to provide 3-(6-carboxy-pyridin-3-ylmethyl)-7-methyl-4-oxo-1-phenyl-1,4-dihydro[1,8]naphthyridine-2-carboxylic acid methyl ester (0.11 g). M+H=430.

Provenance & Evidence