Ethylamine → HCID 25181984, compound

Participants

Reaction Steps

To 3-(6-carboxy-pyridin-3-ylmethyl)-7-methyl-4-oxo-1-phenyl-1,4-dihydro[1,8]-naphthyridine-2-carboxylic acid methyl ester (0.11 g) in DCM was added BOP (0.14 g), followed by ethylamine (0.016 g) and Hunig's Base (0.06 mL), and the mixture stirred at RT overnight. The product was taken up in EtOAc and H2O, washed with NaHCO3 (aq), and dried over MgSO4, then filtered, concentrated, and purified by prep TLC using 100% EtOAc, to provide 3-(6-ethylcarbamoyl-pyridin-3-ylmethyl)-7-methyl-4-oxo-1-phenyl-1,4-dihydro[1,8]-naphthyridine-2-carboxylic acid methyl ester (compound 101) as an off-white solid. M+H=457.

Provenance & Evidence