HCID 66816724, compound → HCID 59846231, compound

Participants

Reaction Steps

Oxazole-2-carboxylic acid [5-chloro-2-(3-phenyl-propionyl)-phenyl]-phenyl-amide (387 mg) was dissolved in dry MeOH (20 mL) and K2CO3 (100 mg), and heated at reflux for 1.5 h. The product was then cooled, the solvent evaporated, and the residue chromatographed (0-30% MeOH/DCM) to provide 3-benzyl-7-chloro-2-oxazol-2-yl-1-phenyl-1H-quinolin-4-one (Compound 140, 233 mg). mp=219.0-220.0° C.

Provenance & Evidence