Methyl chloroglyoxylate → HCID 66816087, compound

Participants

Reaction Conditions

Reaction Steps

3-(4-Methanesulfonyl-phenyl)-1-[6-methyl-2-(3-nitrophenylamino)-pyridin-3-yl]-propan-1-one (0.1 g) was dissolved in THF (5 mL). Chloro-oxo-acetic acid methyl ester (0.1 mL) was added, and the mixture heated by microwave at 80° C. for 1 h. The product was concentrated, the residue taken up in MeOH (5 mL), K2CO3 (0.1 g) added, and the mixture heated at 50° C. for 15 min. The product was cooled and concentrated, and purified by prep TLC (50% EtOAc/hexane) to provide 3-benzyl-7-methyl-1-(3-nitrophenyl)-4-oxo-1,4-dihydro[1,8]-naphthyridine-2-carboxylic acid methyl ester (Compound 104, ˜20 mg). M+H=508.

Provenance & Evidence