HCID 66816087, compound → HCID 66816215, compound

Participants

Reaction Steps

Compound 104 (15 mg) was dissolved in EtOAc (10 mL) with Pc/C (10%, 5 mg), and hydrogenated using H2 (balloon) for 2 h. The product was filtered, concentrated, and purified by prep TLC (50/50 EtOAc/hexane), then 10% MeOH/DCM to provide 1-(3-amino-phenyl)-3-benzyl-7-methyl-4-oxo-1,4-dihydro[1,8]naphthyridine-2-carboxylic acid methyl ester (Compound 105, 2.4 mg). M+H=478.

Provenance & Evidence