Hydroxyamine hydrochloride → HCID 59846159, compound

Participants

Reaction Steps

A solution of 3-benzyl-7-chloro-1-[6-(2,5-dimethyl-pyrrol-1-yl)-pyridin-2-yl]-2-oxazol-2-yl-1H-quinolin-4-one (640 mg) in EtOH (3.5 mL) and water (1.3 mL) and hydroxylamine hydrochloride (450 mg) was stirred for 48 h at 60° C. After evaporation of volatiles, the dark brown residue was partitioned into EtOAc and H2O, and the organic phase adsorbed on silica to provide 1-(6-amino-pyridin-2-yl)-3-benzyl-7-chloro-2-oxazol-2-yl-1H-quinolin-4-one (Compound 141). M+H=428; mp=279.3-282.8° C.

Provenance & Evidence