2,2-Dichloro-3-oxocyclobutyl pivalate → 3-Oxocyclobutyl pivalate

HRID 1697217노트

반응식

HRID 1697217 반응식
[C:1]([O:7][CH:8]1[CH2:11][C:10](=[O:12])[C:9]1(Cl)Cl)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3]>CC(O)=O.[Zn]>[C:1]([O:7][CH:8]1[CH2:11][C:10](=[O:12])[CH2:9]1)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3]

참가 물질

4

반응물 1

HCID 575158702,2-Dichloro-3-oxocyclobutyl pivalate

생성물 1

HCID 533969923-Oxocyclobutyl pivalate

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 176Acetic Acid용매2회

실험 절차

To a stirred suspension of zinc dust (103 g, 1568 mmol) in HOAc (200 ml) was added a solution of 2,2-dichloro-3-oxocyclobutyl pivalate (75 g, 314 mmol) in HOAc (400 ml) dropwise in an ice bath. The reaction mixture was stirred for 1 h, filtered the solid through celite and washed with DCM. The DCM layer was washed with H2O, NaHCO3, brine, dried over MgSO4, filtered and concentrated. The crude material was purified by ISCO (10% EtOAc/Hexanes) to give the title compound as a light yellow oil.

후처리

  1. filtrationfiltered the solid through celite
  2. washwashed with DCM
  3. washThe DCM layer was washed with H2O, NaHCO3, brine
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customThe crude material was purified by ISCO (10% EtOAc/Hexanes)

출처 및 근거

ORD 기록
ord-ff62792840064aedb7780d0e9bad53bf
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08163909B2

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