Trifluoroacetic acid → HCID 59534031, compound

Participants

Reaction Steps

1 ml trifluoroacetic acid is pipetted into 130 mg diethyl {[(6-tert.-butoxycarbonylamino-naphthalen-2-yl)-(3,5-dichloro-phenylsulphonyl)-amino]-methyl}-phosphonate in 3 ml methylene chloride. The reaction mixture is stirred for two and a half hours at ambient temperature, then made alkaline with 1 N sodium hydroxide solution and extracted with methylene chloride. The combined organic phases are washed with saturated sodium chloride solution, dried on magnesium sulphate and evaporated down. The flask residue is chromatographed through a silica gel column with cyclohexane/ethyl acetate (40:60 to 0:100).

Provenance & Evidence