Water → HCID 59533958, compound

Participants

Reaction Steps

115 mg tetrabutylammonium fluoridetrihydrate are added to 155 mg diethyl {[(3,5-dichloro-phenylsulphonyl)-(2-trimethylsilanylethynyl-naphthalen-1-yl)-amino]-methyl}-phosphonate in 4 ml of tetrahydrofuran at ambient temperature. The reaction mixture is stirred for 15 minutes at ambient temperature, then it is mixed with water and extracted with ethyl acetate. The combined extracts are dried on magnesium sulphate and evaporated down. The flask residue is chromatographed through a silica gel column with cyclohexane/ethyl acetate (50:50) as eluant.

Provenance & Evidence