HCID 59534044, compound → {[(3,5-Dichloro-phenylsulphonyl)-naphthalen-2-yl-amino]-methyl}-phosphonic acid

HRID 1697278Notes

Reaction equation

HRID 1697278 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]([CH2:23][P:24](=[O:41])([O:33]CC2C=CC=CC=2)[O:25]CC2C=CC=CC=2)[C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=2)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1>CO.[Pd]>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]([CH2:23][P:24](=[O:25])([OH:33])[OH:41])[C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[CH:14]=2)(=[O:11])=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

4

Reactant 1

HCID 59534044HCID 59534044, compound

Product 1

HCID 25190980{[(3,5-Dichloro-phenylsulphonyl)-naphthalen-2-yl-amino]-methyl}-phosphonic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

72 mg dibenzyl {[(3,5-dichloro-phenylsulphonyl)-naphthalen-2-yl-amino]-methyl}-phosphonate in 6 ml of methanol are hydrogenated in the presence of 3 mg palladium on activated charcoal (10% Pd). The catalyst is filtered through kieselguhr and the filtrate is evaporated down in vacuo. The flask residue is stirred with diisopropylether, suction filtered and dried.

Workup

  1. filtrationThe catalyst is filtered through kieselguhr
  2. customthe filtrate is evaporated down in vacuo
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-e7f40591e54b4352a2d37238b414ed2a
Source dataset
uspto-grants-2012_04
Patent number
US08163911B2

Reaction notes

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