HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1697396Generated: October 30, 2026
1-Bromo-2-Chloroethane → Methyl 3-[3-({1-[2-(2-chloroethoxy)phenyl]cyclopropyl}amino)-2-oxopyrazin-1(2H)-yl]-4-methylbenzoate
https://huagongshe.com/reaction/1697396
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Bromo-2-Chloroethane | HCID 7849 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 3-(3-(1-(2-hydroxyphenyl)cyclopropylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate | HCID 66689475 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Methyl 3-[3-({1-[2-(2-chloroethoxy)phenyl]cyclopropyl}amino)-2-oxopyrazin-1(2H)-yl]-4-methylbenzoate | HCID 66689567 | — |
Reaction Steps
A solution of methyl 3-(3-(1-(2-hydroxyphenyl)cyclopropylamino)-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate (Example 167c) 0.45 g) dissolved in acetonitrile (8 mL) was treated with potassium carbonate (1.589 g) and 1-bromo-2-chloroethane (0.953 mL) under nitrogen. The resulting suspension was stirred at 83° C. for 10 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08163905B2 |
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| Source dataset | uspto-grants-2012_04 |
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| ORD ID | ord-2022de3efeae4de493a83c9938d157d1 |
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| Source note | uspto-grants-2012_04 |
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