Ethanol → p-Toluenesulfonic acid

Participants

Reaction Steps

A rapidly stirring solution of the free base in ethyl acetate-ethanol or ethanol was treated with either p-toluenesulfonic acid monohydrate (1 equivalent; Aldrich; added as a solution in ethyl acetate) or HCl-dioxane (1-2 equivalent; 4 M; Aldrich) at room temperature. After stirring for 2-16 hours, the precipitate was collected by filtration, rinsed with ethyl acetate, and dried to afford the p-toluenesulfonate salt or the hydrochloride salt.

Provenance & Evidence