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Methanesulfonate → (2S,4R)-2-(1-cyano-cyclopropylcarbamoyl)-4-(4-imidazol-1-yl-phenylsulfanyl)-pyrrolidine-1-carboxylic acid t-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanesulfonate | HCID 85257 | — |
| 反応物 | 4-(1H-Imidazol-1-yl)benzene-1-thiol | HCID 21481651 | — |
| 反応物 | (2S,4S)-2-(1-cyano-cyclopropylcarbamoyl)-4-methanesulfonyloxy-pyrrolidine-1-carboxylic acid t-butyl ester | HCID 59543742 | — |
| 生成物 | (2S,4R)-2-(1-cyano-cyclopropylcarbamoyl)-4-(4-imidazol-1-yl-phenylsulfanyl)-pyrrolidine-1-carboxylic acid t-butyl ester | HCID 67278336 | — |
反応手順
The reaction of the mesylate from experiment A2 with 4-imidazol-1-yl-benzenethiol (prepared according to patent application FR 2267101, 1975) yielded (2S,4R)-2-(1-cyano-cyclopropylcarbamoyl)-4-(4-imidazol-1-yl-phenylsulfanyl)-pyrrolidine-1-carboxylic acid t-butyl ester as a colorless foam. MS: 454.2 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08163793B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-550e248eb0454f3fb03b5dc3de0526ad |
| 出典メモ | uspto-grants-2012_04 |