HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichlorobenzenethiol → (2S,4R)-2-(1-cyano-cyclopropylcarbamoyl)-4-(2,4-dichloro-phenylsulfanyl)-pyrrolidine-1-carboxylic acid t-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichlorobenzenethiol | HCID 70730 | — |
| Reactant | Methanesulfonate | HCID 85257 | — |
| Reactant | (2S,4S)-2-(1-cyano-cyclopropylcarbamoyl)-4-methanesulfonyloxy-pyrrolidine-1-carboxylic acid t-butyl ester | HCID 59543742 | — |
| Product | (2S,4R)-2-(1-cyano-cyclopropylcarbamoyl)-4-(2,4-dichloro-phenylsulfanyl)-pyrrolidine-1-carboxylic acid t-butyl ester | HCID 67278396 | — |
Reaction Steps
The reaction of the mesylate from experiment A2 with 2,4-dichlorothiophenol yielded ((2S,4R)-2-(1-cyano-cyclopropylcarbamoyl)-4-(2,4-dichloro-phenylsulfanyl)-pyrrolidine-1-carboxylic acid t-butyl ester as a colorless oil. MS: 454.3 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163793B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-c48dd0312d064ac0a7a6903d90e250b7 |
| Source note | uspto-grants-2012_04 |