HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonate → (2S,4R)-4-(4-bromo-2-trifluoromethyl-phenylsulfanyl)-2-(1-cyano-cyclopropylcarbamoyl)-pyrrolidine-1-carboxylic acid t-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonate | HCID 85257 | — |
| Reactant | 4-Bromo-2-(trifluoromethyl)benzenethiol | HCID 50997997 | — |
| Reactant | (2S,4S)-2-(1-cyano-cyclopropylcarbamoyl)-4-methanesulfonyloxy-pyrrolidine-1-carboxylic acid t-butyl ester | HCID 59543742 | — |
| Product | (2S,4R)-4-(4-bromo-2-trifluoromethyl-phenylsulfanyl)-2-(1-cyano-cyclopropylcarbamoyl)-pyrrolidine-1-carboxylic acid t-butyl ester | HCID 66771854 | — |
Reaction Steps
The reaction of the mesylate from experiment A2 with 4-bromo-2-trifluoromethyl-benzenethiol yielded (2S,4R)-4-(4-bromo-2-trifluoromethyl-phenylsulfanyl)-2-(1-cyano-cyclopropylcarbamoyl)-pyrrolidine-1-carboxylic acid t-butyl ester as a colorless foam. MS: 436.2 and 434.2 [M+H-Boc]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163793B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-9d46d5b826644b0f9f6e8f369c918717 |
| Source note | uspto-grants-2012_04 |