Cyclohexanecarboxylic acid → HCID 46946220, compound

HRID 1697494Notes

Reaction equation

Cl.[C:2]([CH2:4][NH:5][C:6]([C@@H:8]1[CH2:12][C@@H:11]([S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH2:10][NH:9]1)=[O:7])#[N:3].[CH:22]1([C:28](O)=[O:29])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[C:2]([CH2:4][NH:5][C:6]([C@@H:8]1[CH2:12][C@@H:11]([S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(=[O:14])=[O:15])[CH2:10][N:9]1[C:28]([CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1)=[O:29])=[O:7])#[N:3]

Participants

Reactant 2

HCID 7413Cyclohexanecarboxylic acid

HCID 86646810HCID 86646810, compound

Product 1

HCID 46946220HCID 46946220, compound

Procedure

L2. (2S,4R)-4-Benzenesulfonyl-pyrrolidine-2-carboxylic acid cyanomethyl-amide hydrochloride prepared in analogy to experiment K1 was coupled with cyclohexanecarboxylic acid in analogy to experiment A1 to give (2S,4R)-4-benzenesulfonyl-1-cyclohexanecarbonyl-pyrrolidine-2-carboxylic acid cyanomethyl-amide as a white solid. MS: 404.3 [M+H]+.

Sources & evidence

ORD record: ord-eae850e3d28e4dda8b8df97c385d2763
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163793B2

Reaction notes

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