Cyclohexanecarboxaldehyde → HCID 86646812, compound

HRID 1697496Notes

Reaction equation

HRID 1697496 reaction equation
Cl.[C:2]([CH2:4][NH:5][C:6]([C@@H:8]1[CH2:12][C@@H:11]([S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH2:10][NH:9]1)=[O:7])#[N:3].[CH:22]1([CH:28]=O)[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[C:2]([CH2:4][NH:5][C:6]([C@@H:8]1[CH2:12][C@@H:11]([S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(=[O:14])=[O:15])[CH2:10][N:9]1[CH2:28][CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1)=[O:7])#[N:3]

Participants

3

Reactant 2

HCID 16275CyclohexanecarboxaldehydeHCID 86646810HCID 86646810, compound

Product 1

HCID 86646812HCID 86646812, compound

Procedure

L4. (2S,4R)-4-Benzenesulfonyl-pyrrolidine-2-carboxylic acid cyanomethyl-amide hydrochloride prepared in analogy to experiment K1 was reductively aminated with cyclohexanecarbaldehyde in analogy to experiment L3 to give (2S,4R)-4-benzenesulfonyl-1-cyclohexylmethyl-pyrrolidine-2-carboxylic acid cyanomethyl-amide as a white solid. MS: 390.4 [M+H]+.

Sources & evidence

ORD record
ord-e2c27aae83934cedaf623905e40c2408
Source dataset
uspto-grants-2012_04
Patent number
US08163793B2

Reaction notes

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