4-Fluorobenzoic Acid → HCID 46946223, compound

HRID 1697517Notes

Reaction equation

HRID 1697517 reaction equation
Cl.[C:2]([C:4]1([NH:7][C:8]([C@@H:10]2[CH2:14][C@@H:13]([S:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])(=[O:17])=[O:16])[CH2:12][NH:11]2)=[O:9])[CH2:6][CH2:5]1)#[N:3].[F:25][C:26]1[CH:34]=[CH:33][C:29]([C:30](O)=[O:31])=[CH:28][CH:27]=1>>[C:2]([C:4]1([NH:7][C:8]([C@@H:10]2[CH2:14][C@@H:13]([S:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])(=[O:17])=[O:16])[CH2:12][N:11]2[C:30](=[O:31])[C:29]2[CH:33]=[CH:34][C:26]([F:25])=[CH:27][CH:28]=2)=[O:9])[CH2:6][CH2:5]1)#[N:3]

Participants

3

Reactant 2

HCID 99734-Fluorobenzoic AcidHCID 66770259HCID 66770259, compound

Product 1

HCID 46946223HCID 46946223, compound

Procedure

(2S,4R)-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide hydrochloride from experiment K4 was coupled with 4-fluoro benzoic acid in analogy to experiment A1 to give (2S,4R)-4-(2-chloro-benzenesulfonyl)-1-(4-fluoro-benzoyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide as an amorphous white solid. MS: 476.0 [M+H]+.

Sources & evidence

ORD record
ord-f9b6504c77104b6da3563fc59ee31ee0
Source dataset
uspto-grants-2012_04
Patent number
US08163793B2

Reaction notes

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