Cyclobutanone → HCID 46946612, compound

HRID 1697523Notes

Reaction equation

Cl.[C:2]([C:4]1([NH:7][C:8]([C@@H:10]2[CH2:14][C@@H:13]([S:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])(=[O:17])=[O:16])[CH2:12][NH:11]2)=[O:9])[CH2:6][CH2:5]1)#[N:3].[C:25]1(=O)[CH2:28][CH2:27][CH2:26]1>>[C:2]([C:4]1([NH:7][C:8]([C@@H:10]2[CH2:14][C@@H:13]([S:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[Cl:24])(=[O:17])=[O:16])[CH2:12][N:11]2[CH:25]2[CH2:28][CH2:27][CH2:26]2)=[O:9])[CH2:6][CH2:5]1)#[N:3]

Participants

Reactant 2

HCID 14496Cyclobutanone

HCID 66770259HCID 66770259, compound

Product 1

HCID 46946612HCID 46946612, compound

Procedure

(2S,4R)-4-(2-chloro-benzenesulfonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide hydrochloride from experiment K4 was reductively aminated with cylobutanone in analogy to experiment L3 to give (2S,4R)-4-(2-chloro-benzenesulfonyl)-1-cyclobutyl-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide as a colorless oil. MS: 408.3 [M+H]+.

Sources & evidence

ORD record: ord-eaa05e30885b4c6494e5592fd987610d
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163793B2

Reaction notes

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